Question 1

Is Mounjaro better than Ozempic for weight loss?

Accepted Answer

Clinical trial data suggests Mounjaro (tirzepatide) achieves greater average weight loss than Ozempic (semaglutide 1mg) — approximately 20% vs 12–14% body weight reduction. However, Ozempic is not licensed for weight loss in the UK; Wegovy (semaglutide 2.4mg) is the weight-loss-specific version of semaglutide. For weight loss, the comparison is typically Mounjaro vs Wegovy.

Question 2

Can I switch from Ozempic to Mounjaro?

Accepted Answer

Yes, it is possible to switch from Ozempic to Mounjaro, but this should be done under medical supervision. Your prescriber will advise on the appropriate starting dose for Mounjaro and any washout period required. Do not switch medications without consulting your prescriber.

Question 3

Is Ozempic available for weight loss in the UK?

Accepted Answer

Ozempic (semaglutide 0.5mg, 1mg, 2mg) is licensed in the UK for type 2 diabetes management, not specifically for weight loss. Wegovy (semaglutide 2.4mg) is the MHRA-approved weight loss version. Some UK prescribers prescribe Ozempic off-label for weight loss, but this is less common since Wegovy became widely available.

Question 4

Which is cheaper — Mounjaro or Ozempic in the UK?

Accepted Answer

Mounjaro typically costs £129–£249 per pen in the UK depending on dose and pharmacy. Ozempic costs approximately £80–£150 per pen. However, since Ozempic is primarily for diabetes, weight-loss patients usually compare Mounjaro vs Wegovy, which is similarly priced to Mounjaro.

Question 5

What is the difference between Ozempic and Wegovy?

Accepted Answer

Both contain semaglutide, but at different doses. Ozempic is available in 0.5mg, 1mg, and 2mg doses for type 2 diabetes. Wegovy is available in doses up to 2.4mg, specifically licensed for weight management. Wegovy's higher dose is what produces the greater weight loss seen in STEP clinical trials.

Question 6

Do Mounjaro and Ozempic have the same side effects?

Accepted Answer

Both medications share similar GI side effects (nausea, vomiting, diarrhoea, constipation) as they both act on GLP-1 receptors. Mounjaro additionally acts on GIP receptors, which may contribute to its greater efficacy. Side effect profiles are broadly similar, though individual experiences vary.

Feature	Mounjaro Tirzepatide	Ozempic Semaglutide
Active ingredient	Tirzepatide	Semaglutide
Mechanism	Dual GIP + GLP-1 agonist	GLP-1 agonist only
Injection frequency	Once weekly	Once weekly
Licensed for weight loss (UK)	✓ Yes (Mounjaro)	✗ No (Wegovy is)
Average weight loss	~20% body weight	~12–14% body weight
Starting dose	2.5mg	0.25mg
Maximum dose	15mg	2mg (Ozempic) / 2.4mg (Wegovy)
UK price range	£129–£249 per pen	£80–£150 per pen
MHRA approved	✓ Yes	✓ Yes (for diabetes)
NHS availability	Specialist clinics only	Prescribed for T2D
Manufacturer	Eli Lilly	Novo Nordisk
Clinical trial	SURMOUNT	STEP / SUSTAIN

Mounjaro vs Ozempic UK 2025

The Short Answer

Mounjaro vs Ozempic — Full Comparison

Mounjaro (Tirzepatide)

Ozempic (Semaglutide)

Clinical Trial Results

Mounjaro — SURMOUNT-1

Ozempic — STEP 1 (Wegovy dose)

Mounjaro vs Ozempic — FAQs

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