Mounjaro vs Wegovy UK: Which Weight Loss Injection Is Right for You?
Both Mounjaro (tirzepatide) and Wegovy (semaglutide) are MHRA-approved weekly injections for weight management in the UK. This guide compares clinical trial outcomes, UK prices, side effects, and suitability to help you make an informed decision with your prescriber.
ExpressDiscountCode Verdict
Mounjaro generally produces greater weight loss (up to 22.5% vs 15% in clinical trials) and is often cheaper per month in the UK. Wegovy has a longer safety track record and additional cardiovascular benefits. For most new patients without contraindications, Mounjaro is currently the stronger choice — but always discuss with your prescriber.
Head-to-Head Comparison
Key facts compared side by side. Updated 27 March 2026.
| Feature | Mounjaro | Wegovy |
|---|---|---|
| Active ingredient | Tirzepatide | Semaglutide |
| Mechanism | Dual GIP + GLP-1 agonist | GLP-1 agonist only |
| Injection frequency | Once weekly | Once weekly |
| Starting dose | 2.5mg | 0.25mg |
| Maximum dose | 15mg | 2.4mg |
| Avg. weight loss (trials) | Up to 22.5% | Up to 15% |
| UK approval status | MHRA approved (2023) | MHRA approved (2022) |
| NHS availability | Limited (NICE 2024) | Limited |
| Cheapest UK private price | ~£121/month | ~£150/month |
| Pen device | KwikPen (auto-injector) | Pen injector |
| Manufacturer | Eli Lilly | Novo Nordisk |
* Weight loss figures from SURMOUNT-1 (tirzepatide) and STEP-1 (semaglutide) clinical trials. Individual results vary. Always consult a prescriber.
Pros & Cons
Mounjaro (Tirzepatide)
Wegovy (Semaglutide)
Clinical Trial Weight Loss Data
Both medications have been tested in large-scale randomised controlled trials. The figures below represent average weight loss at the highest approved dose over approximately 68–72 weeks.
Average body weight reduction over 72 weeks vs placebo
Average body weight reduction over 68 weeks vs placebo
Clinical trial results represent averages under controlled conditions. Individual weight loss varies based on starting weight, diet, exercise, adherence, and other factors. These figures should not be used as personal weight loss predictions. Always consult a qualified prescriber.
UK Price Comparison
Private prescription prices vary significantly between UK pharmacies. The table below shows indicative price ranges for each medication at their starting and maintenance doses. Use our full comparison tools to find the cheapest verified price.
| Dose | Mounjaro (from) | Wegovy (from) |
|---|---|---|
| Starting dose | £121/month (2.5mg) | ~£150/month (0.25mg) |
| Mid titration | £144/month (5mg) | ~£170/month (0.5mg) |
| Maintenance | £260/month (10mg) | ~£250/month (1.7mg) |
| Full maintenance | £260/month (15mg) | ~£250/month (2.4mg) |
Prices are indicative and based on the cheapest verified prices on ExpressDiscountCode as of 27 March 2026. Wegovy prices are approximate as we do not currently track all Wegovy pharmacies. Always verify at checkout.
Mounjaro vs Wegovy: Frequently Asked Questions
Mounjaro and Wegovy are prescription-only medicines. This page is for informational purposes only and does not constitute medical advice. Always consult a qualified UK prescriber before starting, switching, or stopping any weight loss medication. ExpressDiscountCode is a price comparison and information service.
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